An amplifier circuit (100) has an input stage (OP1) and an output stage (Ql, Q2) operating with different supply voltages and different quiescent voltages. The output stage has a feedback input connected to receive a feedback signal from the output of the output stage. A biasing circuit (602) applies a bias signal (Ioff) to said input stage at an operating level appropriate to establish a quiescent output voltage different from a ground reference level of the input stage. To start up the amplifier with minimal transients at the output, the following steps are performed in sequence: (a) with the output stage disabled, pre-charging the amplifier output over a period of time to a level (Vmid) corresponding to the ground reference level of the input stage; (b) with the biasing circuit effectively disabled and a zero input signal at said signal input, enabling the input and output stages; (c) activating said biasing circuit progressively so as to ramp said bias signal (Ioff) to said operating level over a further period of time, thereby driving the output progressively to said quiescent output voltage. A separate improvement is in the biasing circuit, which uses the actual output stage supply voltage (PVdd) as a reference to define the operating level of said bias signal (Ioft).
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